Bioproton

Influence of beam pruning techniques on LET and RBE in proton arc therapy

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kristianuib
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A paper exploring spot selection in proton therapy planning and its impact on linear energy transfer and relative biological effectiveness. First author Helge Henjum (helge.henjum@uib.no) is Post Doc. in the Bioproton project.

The Eclipse treatment planning system was used together with a FLUKA MC based tool to optimize proton treatment plans by spot pruning – removing high energy spots in the target. The effect of higher degrees of pruning are shown in the figure below, illustrating the potential to increase the LET in the tumor through smart spot selection.

LETd volume histogram for the PTV, surrounding healthy tissue and the OARs calculated with 2 Gy(RBE1.1) dose cutoffs for the germinoma case. The dashed lines represent the Pruned-PAT plans, while the solid black lines represent the PAT plan and the solid gray line represent the IMPT plan.

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