Category: Publications
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An updated variable RBE model for proton therapy
This paper was published in Physics in Medicine and Biology 2024. This study establishes an comprehensive in-vitro database for protons and examines previously published models and model assumptions in light of this new data. First author Erlend Lyngholm also proposes a new variable RBE model. based on the current analysis and data. Underneath you can…
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Dose exposure to an adult present in the treatment room during pediatric pencil beam scanning proton therapy
The paper published in Acta Oncologica post Bigart 2023 conference explores dose exposures in proton therapy treatment rooms. Author Johannes Tjelta’s FLUKA monte carlo simulations estimate organ mean equivalent doses and mean body dose, all within tenths of µSv per treatment Gray. Findings suggest low radiation exposure risk, prompting consideration for further studies on caretaker…
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Linear energy transfer-inclusive brainstem necrosis risk models applied to an independent paediatric proton therapy cohort
The study in Acta Oncologica focuses on radiation-induced brainstem necrosis, especially in paediatric patients with CNS tumors. It explores the application of NTCP models to estimate and reduce the risk of brainstem necrosis, emphasizing the potential of LET optimization in proton plans to minimize this risk. The findings stress the importance of considering both dose…
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Linear energy transfer-inclusive models of brainstem necrosis following proton therapy of paediatric ependymoma
This study investigated the association between brainstem necrosis and radiation therapy in pediatric ependymoma patients. The research found that higher linear energy transfer (LET) in the brainstem correlated with increased necrosis risk, highlighting the importance of managing LET during treatment planning. The logistic regression models demonstrated this relationship and its potential impact on patient care.
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Influence of beam pruning techniques on LET and RBE in proton arc therapy
The paper investigates spot selection in proton therapy planning and its impact on linear energy transfer (LET) and relative biological effectiveness (RBE). Using the Eclipse treatment planning system and a FLUKA MC-based tool, the study demonstrates the potential to increase LET in the tumor through smart spot selection, as illustrated in the figure.
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A systematic approach for calibrating a Monte Carlo code to a treatment planning system
The paper details a systematic methodology for calibrating Monte Carlo codes to treatment planning systems, facilitating advanced studies of dose, LET, RBE, and other quantities including secondary particles. Johannes Tjelta, a PhD student at UiB and Haukeland University Hospital, presents a step-by-step approach for calibration. For more information, the author can be reached at Johannes.Tjelta@uib.no.
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Combined RBE and OER optimization for proton therapy
The paper explores the use of Oxygen Enhancement Ratio (OER) and Relative Biological Effectiveness (RBE) in proton therapy planning for head and neck cancer. A FLUKA Monte Carlo-based tool is used to optimize treatment plans, considering tumor hypoxia. It shows potential to improve tumor control compared to conventional methods. (Word count: 49)
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Hypoxia adapted relative biological effectiveness models for proton therapy
The paper by Guillermo Garrido Hernandez investigates different models for Oxygen Enhancement Ratio (OER) and their implications for proton therapy planning. It highlights the clinical importance of understanding the effect of protons in hypoxic cells, offering potential to improve treatment quality. The study reveals that various models yield similar estimates for OER in proton therapy,…
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